The Plus Project is a 4.25-year Unitaid-funded project that has co-designed and piloted, and will evaluate throughout the life of the project, country-adapted models of Perennial Malaria Chemoprevention (PMC) – the latest WHO recommendation which includes what was previously called Intermittent Preventive Treatment in infants – using sulfadoxine-pyrimethamine (SP) in four focus countries: Benin, Cameroon, Cote d’Ivoire, and Mozambique.
The Plus Project is proud to have delivered 10 scientific sessions, 2 symposia, and co-led the PMC community of practice gathering at the Multilateral Initiative on Malaria (MIM) 8th Pan-African Malaria Conference in Kigali, Rwanda, from April 21st – 27th, 2024 under the theme “Grassroots Mobilisation to End Malaria: Invest, Innovate, Integrate.” We also hosted a webinar after MIM to share our symposium with a broader audience that was not able to join the conference. See all final presentations here.
During MIM, we shared lessons learned and project outputs to generate evidence aimed at accelerating the adoption and scale-up of PMC in the project countries and other malaria-endemic countries of sub-Saharan Africa. Research studies include policy adoption, impact, and economic modeling and evaluations, as well as SP resistance and suitability studies. These learnings from implementation experience and research evidence are intended to help countries decide if and how to use PMC as part of their malaria chemoprevention strategies.
(L-R): Prof Catherine Pitt, LSHTM Plus Project; Dr Junior Voundi Voundi, Chemoprevention Lead from NMCP Cameroon and co-chair of the PMC Community of Practice; Elsa Nhantumbo, Mozambique Country Lead Plus Project, PSI; Prof Gillian Stresman, University of South Florida, Plus Project; Meredith Centre, former Plus Project Director and now Path Deputy Director for malaria and NTDs; Prof Matt Chico, LSHTM Plus Project; Lilly Claire, the Plus Project Regional Technical Advisor and Cameroon Country Lead; Dr Jacques Kouakou, the Plus Project Deputy Project Director; and Dr Jane Grant, LSHTM Plus Project
Photo credit: Henry Ntuku, PATH, member of the PMC Community of Practice
Opening Day
Ahead of the welcoming plenary in the evening, the RBM Partnership to End Malaria and Medicines for Malaria Ventures (MMV) held two workshops focused on gender equality and malaria. These discussions championed women and elevated the importance of community participation and co-creation as key components of gender equity to ensure identification of local solutions in the context of those communities. The Plus Project is equally committed to gender-conscious and socially inclusive solutions for sustainability. Early on, the project conducted a gender analysis to identify critical insights into gender norms, barriers, and opportunities across the project’s focus countries. Using the results from this analysis, the team adopted a multifaceted approach to mitigate the effects of gender and social inclusion on health outcomes.
Later at the MIM welcoming plenary, the Plus Project joined attendees for a keynote address by the Honorable Dr. Sabin Nsanzimana, Minister of Health for Rwanda. Dr. Nsanzimana’s remarks underscored the importance of sustained commitment and innovative approaches in the fight against malaria, emphasizing the need for continued partnership and investment in research, prevention, and treatment strategies. His inspiring call was echoed among the audience, “Our generation can end #malaria! Let’s keep fighting together to achieve a zero-malaria world, so that we do not pass the burden to our grandchildren.”
Photo credit: Multilateral Initiative on Malaria
Tuesday, April 23
We hosted our first symposium of the week “Context is everything: adapting national PMC strategies to community realities in Benin, Cameroon, Côte d’Ivoire and Mozambique.”
This symposium showed how the co-design process at the beginning of the Plus Project yielded aspirational delivery schedules anticipating the introduction of the Measles 2 vaccine and the routinization of vitamin A. As implementation progressed it became clear that fewer children attend EPI clinics in the second year of life than in the first, and that vitamin A is most often taken up through campaigns rather than through the EPI clinics. As a result, PMC needs to be coupled with EPI and vitamin A outreach strategies, looking for zero-dose children in the community and taking advantage of campaign opportunities to help children catch up. The Healthy Child Consultation in Mozambique provides an alternative approach that could be applicable in other countries with good community adherence to child growth monitoring appointments.
We were thrilled to welcome a full room including vital partners from national malaria programs, and hosted this session virtually on June 4th to share with those who were not able to attend MIM.
(Panel L-R): Dr Junior Voundi Voundi, Chemoprevention Lead from NMCP Cameroon and co-chair of the PMC Community of Practice; Dr Jacques Kouakou, the Plus Project Deputy Project Director; and Lilly Claire, the Plus Project Regional Technical Advisor and Cameroon Country Lead. Photo credit: Multilateral Initiative on Malaria
Front row (L-R): Charlotte Eddis, Plus Project Director, PSI; Lilly Claire, the Plus Project Regional Technical Advisor and Cameroon Country Lead, PSI; Bienvenu Wakpo, Benin Country Lead, PSI. Second row (L-R): Paul Bouanchaud, PSI Senior Research Advisor; Dr William Houndjo, NMCP Benin Chemoprevention Lead and PMC Community of Practice co-chair. Photo credit: Multilateral Initiative on Malaria
In the evening, we hosted a special side meeting on PMC and malaria vaccine co-implementation on behalf of the PMC Community of Practice. This stakeholder discussion on co-implementation policy, research, and operational priorities was well attended, with presentations by Dr Jane Grant and Professor Roly Gosling of the Plus Project at LSHTM, Dr Mary Hamel the Malaria Vaccine Team Lead at WHO, and Dr Shalom Ndoula the EPI Program Coordinator at the Cameroon Ministry of Health. This was a follow up to a similar meeting at ASTMH in 2023. A subset of the PMC Community of Practice (Jane Grant, Roly Gosling, Jayne Webster (Plus Project at LSHTM) and Henry Ntuku (PATH)) had distilled key questions from the participants of the ASTMH meeting to those with immediate need for answering and vital information for further investment in PMC and/or co-implementation into a roadmap.
Prof Roly Gosling, LSHTM Plus Project Technical Director, presenting the roadmap on the co-implementation of SP and the malaria vaccine. Photo credit: Multilateral Initiative on Malaria
Dr Mary Hamel, Malaria Vaccine Team Lead at WHO, presenting to a well-attended special side meeting sponsored by the Plus Project. Photo credit: PSI Plus Project
Wednesday, April 24
We joined the plenary session on “Climate Change and its Impact on Malaria Elimination” focused on how changing weather patterns influence malaria risk. There is a need to predict the direct impacts of pressure on malaria risk across southern, central, and east Africa and the potential amplification of indirect factors such as the effects by socioeconomic and how it hampers equitable development and disrupts malaria control and could ultimately amplify direct effects. PSI and the Plus Project are committed to addressing challenges and pursuing solutions that live at the interaction of climate and health.
Photo credit: Multilateral Initiative on Malaria
Thursday, April 25 (World Malaria Day)
We joined the more than 1,500 scientists, policymakers, and advocates at MIM to celebrate World Malaria Day! This year’s theme was “Accelerating the fight against malaria for a more equitable world” which was the red thread throughout all sessions at the conference. To mark the global celebration (and International Women’s Day in March), we shared this video of mothers in Mozambique that have joined together to walk hours to the nearest health facility to receive routine vaccinations, including SP for PMC, for their young children.
We also gave three scientific presentations, one on diagnosis and treatment and three on chemoprevention:
- “Coverage of Perennial Malaria Chemoprevention (PMC) challenged by few vaccination clinic (EPI) visits in the second year of life”
- “A systematic review of non-malarial effects of malaria chemoprevention interventions”
- “The Mozambican Healthy Child Consultation is an extraordinary platform for delivering perennial malaria chemoprevention”
Sadate Soumahoro from the Plus Project presenting during the scientific session on challenges in second year of life. Photo credit: PSI Plus Project
That evening, all attendees gathered for the World Malaria Day celebration. The co-chairs of the MIM Conference Scientific Committee shared while “World Malaria Day is a day to recognize the tireless efforts of healthcare workers, researchers, and all involved in eliminating malaria” we all have a role to play in keeping “the momentum towards ending malaria.” The session also featured an important panel of national malaria program managers from Burkina Faso, Cabo Verde, Rwanda, and Uganda on their successes and challenges in the elimination of malaria.
Photo credit: Multilateral Initiative on Malaria
Friday, April 26
On the final day of the MIM conference, we hosted another symposium and three scientific sessions, one on chemoprevention and two on drug resistance:
- “Acceptability and Barriers to Implementation of Vitamin A Supplementation and its Potential role in the Co-delivery of Perennial Malaria Chemoprevention”
- “Surveillance of antimalarial resistance markers to inform SP suitability for Perennial Malaria Chemoprevention in Cote d’Ivoire”
- “Characterisation of Plasmodium falciparum antimalarial drug resistance marker profiles in polyclonal/mixed infections by Illumina targeted sequencing”
Our symposium “Evidence to support decision-making across Africa: Development of a decision tool for Perennial Malaria Chemoprevention (PMC)” focused on a Decision Tool for Perennial Malaria Chemoprevention. We shared how the various research workstreams under the Plus Project – from molecular genotyping to economic evaluation to modeling – will be brought together into a Decision Tool to help national programs determine the most appropriate places to target the intervention. This tool will be finalized and disseminated in a webinar around World Mosquito Day in August.
(Panel L-R): Junior Voundi Voundi from NMCP Cameroon; Catherine Pitt, LSHTM; Jane Grant, LSHTM; Akindeh Nji, FINISTECH; Ishana Atkinson from LSHTM; Azizath Moussiliou, CREC; Joseph Tankwa, LSHTM. Photo credit: PSI Plus Project
Photo credit: PSI Plus Project
In the closing ceremony, we reflected on a week of informative sessions, successful networking and information sharing, and overall hope for what is to come in the global fight against malaria. As Prof. Rose Leke summarized in her closing remarks “What an incredible week in Kigali, Rwanda! MIM concludes on a high note, with renewed commitments, impactful advocacy, and groundbreaking scientific discussions to end malaria in Africa. Let’s carry this momentum forward as we work together towards a malaria-free future.”
Saturday, April 27
After the formal conference had concluded, we hosted the PMC Community of Practice meeting to ensure that all participants could gather and discuss the first draft of a multi-country Operational Handbook which will be co-created and published as a Community of Practice product.
Dr William Houndjo, NCMP Benin Chemoprevention Lead and co-chair of the PMC Community of Practice, summarized his impressions of the week: “This was my first time at MIM…we learned a lot about chemoprevention. We got information we could use further. We have results on PMC in Benin and we are thinking about how to make PMC available throughout the southern part of the country based on the information we learned at the conference and through the Plus Project.”
Photo credit: PSI Plus Project
Throughout MIM 2024, the Plus Project was thrilled to join partners in recommitting support to national malaria programs in endemic countries to improve malaria services for young children and strengthen national health systems.
Our symposia showcased the importance of tailoring and adapting national PMC strategies to community realities and co-designing those processes with national leaders so that they are appropriate to the specific contexts and to ensure that outcomes meet their national goals.
Our posters and scientific sessions encompassed the breadth and scope of the Plus Project’s support to country-led activities to strengthen national capacities. We will continue to evaluate learnings from our delivery models so that lifesaving interventions like PMC continue to reach those who need it most, ultimately reducing morbidity and mortality due to malaria and anemia in children under two.